3'-processing of yeast tRNATrp precedes 5'-processing

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3'-processing of yeast tRNATrp precedes 5'-processing.

Previous analyses of eukaryotic pre-tRNAs processing have reported that 5'-cleavage by RNase P precedes 3'-maturation. Here we report that in contrast to all other yeast tRNAs analyzed to date, tRNA(Trp) undergoes 3'-maturation prior to 5'-cleavage. Despite its unusual processing pathway, pre-tRNA(Trp) resembles other pre-tRNAs, showing dependence on the essential Lsm proteins for normal proces...

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ژورنال

عنوان ژورنال: RNA

سال: 2003

ISSN: 1355-8382

DOI: 10.1261/rna.2145103